Laura M. Boykin, PhD TED Senior Fellow
  • Home
  • People
  • Publications
  • Research
  • News
  • Collaborators
  • Blog
  • Home
  • People
  • Publications
  • Research
  • News
  • Collaborators
  • Blog

Blog - Cassava Warriors

2019- the year of change.

12/30/2019

0 Comments

 
2019 highlights:
  • Proof of concept that sequencing on the farm increases yield for farmers in REAL-TIME.
  • Tree Lab paper is published.
  • TED Talk about the Tree Lab paper came to life after 3 months of HARD work.
  • Pore Safari in DRC and Sierra Leone. See #sequencing4farmers on twitter.
  • Hung out with the President of Sierra Leone
  • Also began collaborations with the EAC.
  • Tree Lab in Democratic Republic of the Congo.
  • 11 papers published
  • Tonny Kinene is now Dr. Kinene
  • Tara completed her Honours with first class distinction.
  • Visitors and collaborators make science manageable.
  • SciFoo at Goggle was fun.
  • WIRED 25 and subsequent trip to the WIRED conference and a WIRED podcast. 
  • We were featured in Fast Company as one of the world changing ideas.
  • Many news stories​
  • My new titles moving into 2020- Social Entrepreneur, CEO, and Co-founder of the Cassava Virus Action Project.  I am most grateful to all who have donated to help this dream come to life.  If you feel inclined to donate here's the link:  https://multiplier.org/project/cassava-virus-action-project/
  • My lab at UWA is closed -I will be out in the farmers' fields now so catch me in the real world. And if you wanna join the collective let me know. Follow along to the new adventures at: https://cassavavirusactionproject.com
0 Comments

2018-  year of diversity and inclusion.

12/31/2018

0 Comments

 
Some significant accomplishments  for me (Laura Boykin) for 2018.  
  1. I received an Honorary Doctorate from The Open University in Manchester, United Kingdom.  I was nominated  "In recognition of your academic and scholarly distinction. You were nominated for this award as a result of the exceptional contribution that you have made to world food security and promoting science and education for all." My mom was there and so proud.  See my speech here (at minute 40).
  2. We sequenced whole cassava virus genomes under farmers' trees in Tanzania, Uganda and Kenya. We called it TreeLab and most told us we could never do it, and we did.  See here for all updates.
  3. We saw Asha, a farmer in Tanzania, go from zero cassava to 40 tonnes/hectare.  It was the best day ever.
  4. 15 papers published in 2018. The best part of this is the diversity of co-authors. I published with people from Tanzania, Kenya, Uganda, Brazil, Zambia, Malaysia, China, United Kingdom, United States of America, Germany, and Mozambique.
  5. 3rd International Whitefly Symposium in Perth. The most diverse and inclusive whitefly event in history.
  6. African Systematics Symposium at the Evolution Meetings.  The most diverse and inclusive symposium at the entire meeting.
  7. Pore Safari 1.0.  (also check twitter #poresafari for all updates). Oxford Nanopore sequencing across east Africa. Tanzania, Kenya and Zambia. We met over 150 scientists from over 35 institutions. The game is changing.  Decentralizing sequencing is the only way forward.  
  8. 2 PhD students are done!  Bruno and James- Congrats!
  9. TED 2017- being a TED Senior Fellow is amazing.
  10. Thank you to the Crawford Fund for financially supporting our work.  
  11. Hosting Tony Bakelana from Democratic Republic of Congo for a month in Perth- where we uncovered what is killing the cassava in DRC. It will ROCK the cassava world in 2019 when we get it all polished and out - stay tuned.
  12. Thank you to all who have stood by me. Special thanks to Dr. Monica Kehoe, Tonny Kinene and Anders Savill who are all based in Perth and have helped me fight the fight of my academic life.
  13. Visiting Langata Womens Prison in Kenya and talking about cassava viruses and whiteflies. Most in prison are there because they are poor- they need skills to grow more cassava for more money when they get out. 
0 Comments

2017 Highlights!

12/31/2017

0 Comments

 
What an amazing year! 2017 was a year of achievements and excitement. Thank you to all who have supported us throughout the year.  Below are my (Laura Boykin) favorite things.
  1. Pocket DNA Sequencing for farmers!  We launched the Cassava Virus Action Project and successfully diagnosed sick plants in Tanzania and Uganda within 48 hours PLUS provided the correct variety to the farmers.
  2. Selected for a TED Senior Fellowship 2017
    1. TED 2017 in Vancouver, Canada
    2. TED Senior Fellows Salon in NYC (saw my first Broadway show on Broadway!)
    3. TED Global, Arusha Tanzania and hosted 2 workshops.
  3. Won the Gifted Citizen Prize for 2017!  More pocket DNA sequencing for farmers in 2018 and beyond!
  4. Launch of Whiteflybase.  Anders Savill worked extremely hard to create a useful species ID tool for B. tabaci.
  5. Our team remained solid and united as we gained freedom from toxic 'collaborators'. 
  6. Team published 8 papers 
    1. Just to highlight one very impactful paper- We uncovered a DAG motif in CBSV which points to other vectors besides whiteflies. Elijah- thank you.
  7. I met Sauti Sol in Arusha! These gentlemen are even nicer in person than I ever imagined. I am hopeful we collaborate in Feb. 2018 when I am in Kenya!
  8. I met Dr. Kizza Besigye, he is an inspiration to me and enjoying a meal at his house in Uganda was a huge highlight for me.  We had chicken and salad and sat and talked for hours about politics and farmers and science.  
  9. Traveled lots of amazing places: 
    1. Canada- peaceful and cold and home of TED.
    2. USA- my beloved country that is struggling with a dictator who is ruining so many things.
    3. Madagascar- the poorest place I have ever visited.  Farmers and people here need our help NOW.
    4. Thailand- very vulnerable to cassava plant viruses, labs need to be built, scientists need resources.
    5. Brazil- a country dealing with financial issues, amazing science, home of cassava.
    6. Tanzania- needs biotechnology, farmers struggling, power and water and internet needed.
    7. Uganda- removal of the dictator, farmers really struggling, power, water and internet needed too.
    8. Ireland- Brexit has them shook, amazing computational biologists, cold yet warm.
    9. Mexico- alive, innovation, a country on the rise.
    10. Melbourne- a place I learned about pocket DNA sequencing with my friend Monica Kehoe. Magic.
    11. United Kingdom- a country divided, the BBC was amazing, genomic technology.
  10. Attended United Nations Solution Summit Bootcamp in Denver.
  11. Serena (4th grader) picked me for her scientist inspiration and made the coolest poster.
  12. Lots of media coverage including BBC, BBC Radio,  CNN, The Economist , TED Blog and many more!
  13. Many outreach lectures including in my hometown a 7th grade science class full of amazing young girls who love science.  
  14. The teams at MARI in Tanzania and NaCRRI in Uganda inspire me to be a better human. The drivers, technicians, admin assistants, guards and all- you were a highlight for me.
  15. Collaborators- Monica, Laura, Joseph, Titus, Peter, Fred, Elijah, Patrick, Renate, Sunadda, Paul- thank you for standing by me and focusing on the science.  2018 we soar even higher.
0 Comments

African based scientists- we need your abstracts for the Evolution meetings in France!

12/13/2017

0 Comments

 
Submit your abstracts to the participate in our Systematics Research in Africa: Impact for Millions HERE. Then  select S37!

S37. Systematics Research in Africa: Impact for millions
The African continent is home to an enormous amount of biodiversity, presenting significant challenges in understanding and managing resources in a manner that respects human interactions with the natural environment. A group of scientists from Kenya, Tanzania, Uganda, Australia and the United States of America have formed a coalition that seeks to utilize advanced phylogenetic, genomic and computational techniques to generate robust phylogenies to aid in understanding this biodiversity. The resulting phylogenetic understanding provides the framework that enables solutions to problems affecting millions of African people, such as food security and disease. In this symposium, we would like to highlight the amazingly innovative and impactful research that is happening on the African continent, including applications in agriculture, biodiversity and medicine. Because much of Africa systematics research has been carried out separately from “mainstream” systematics research, we believe our symposium can contribute to better integration by highlighting current work in Africa, thus providing an opportunity for new collaborations to begin.  Our ultimate goal is a more inclusive, diverse, and vibrant systematics community worldwide.
Invited speaker: Joseph Ndunguru “Translating upstream science into impact and benefit for the poor”

Any questions leave a comment below or email one of us!

​


0 Comments

Cassava brown streak virus has a crazy fast evolutionary rate!

11/3/2016

2 Comments

 
Today our paper is live! 

Alicai, T., Ndunguru, J., Sseruwagi,P., Tairo, F., Okao-Okuja,G. Nanvubya, R., Kiiza, L., Kubatko, K., Kehoe,M.A., and  Boykin, L.M. 2016.  Cassava brown streak virus has a rapidly evolving genome: implications for virus speciation, variability, diagnosis and host resistance. Scientific Reports. 

I have never been more excited or proud of a paper than I am of this one. 10 scientists (5 women and 5 men) from 4 different countries (Uganda, Tanzania, Australia and the USA) united to get to the bottom of the question “Why is CBSV more devastating than UCBSV? 10 people’s voices and contributions shine through in our paper. We listened to each other, we valued each other’s expertise and we did it. Scientific collaboration the way it should be done-respect, trust, determination and kindness.  Did I mention I am super proud of us!
 
Abstract from our paper:
Cassava is a major staple food for about 800 million people in the tropics and sub-tropical regions of the world. Production of cassava is significantly hampered by cassava brown streak disease (CBSD), which is caused by Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV). The disease is suppressing cassava yields in eastern Africa at an alarming rate. Previous studies have documented that CBSV is more devastating than UCBSV because it more readily infects both susceptible and tolerant cassava cultivars, resulting in greater yield losses. Using whole genome sequences from NGS data, we produced the first coalescent-based species tree estimate for CBSV and UCBSV.  This species framework led to the finding that CBSV has a faster rate of evolution when compared with UCBSV. Furthermore, we have discovered that in CBSV, non-synonymous substitutions are more predominant than synonymous substitution and occur across the entire genome. All comparative analyses between CBSV and UCBSV presented here suggest that CBSV may be outsmarting the cassava immune system, thus making it more devastating and harder to control.
 
​ 
Behind the scenes:
Our lead author Dr. Titus Alicai from NaCRRI guided us to answer a question that has been on the minds of cassava breeders and scientists for years- “Why is CBSV more devastating than UCBSV?”.  In June 2015, Dr. Alicai traveled to the University of Western Australia for a month long digging exercise through millions of NGS reads in hopes of finding cassava brown streak viral genomes! But even before he arrived Drs. Joseph Ndunguru, Peter Sseruwagi and Monica Kehoe had spent a month (December 2014) extracting RNA from FTA cards in preparation for NGS sequences. It is a must to give a massive shout-out to Dr. Fred Tairo who has provided key inputs into the lab protocols and insights into how the genes in CBSV work.  AND even before that the amazing crew in Uganda Geoffrey Okao-Okuja, Resty Nanvubya, Lilliane Kiiza had done ALL the hard work. They actually went out into the field and used their expertise to collect symptomatic plants and then carried out further RNA extractions and RT-PCR to verify the plants were infected with CBSD. Dr. Alicai spent a month digging and uncovered 3 new genomes from Uganda and then the fun began! We sat down and thought of our analyses strategy driven by Titus’s own experiences and with cassava breeders (and my stint at LANL where we analyzed HepC and Flu) we decided to analyze the CBSV and UCBSV separately (because plants respond differently to the infections in the field). Low and behold we observed CBSV and UCBSV have very different patterns of substitution across the whole genome (see Figure 2 in our paper).  Fast forward to our push to get this paper out.  We had the pleasure of hosting Prof. Laura Kubatko from Ohio State University at UWA and we showed her the data and told her the story and she was in to help too. She was able to try out her cool new tools SVDQ  and sliding window  and we were back and forth a bunch of times with the team in E. Africa during her visit asking if the analyses we were doing made sense and they were 100% involved in pushing us forward.  We did it. Analyses were complete and we are proud of our teamwork. Plus, in-person visits were KEY to our success
 
When it came to writing the paper- we all did it. We made an outline, headings, subheadings, assigned people sections and we did it. The drafts flew over the next couple months then we hustled the paper and it landed in Scientific Reports. We all put this paper on the top of our priority list because we know it matters.  It matters to get this story out for the farmers in East Africa who are dealing with the devastation caused by these viruses.  It also matters to highlight how a true scientific collaboration can work with respect and trust for a common goal.  Personally, the other 9 coauthors are not just collaborators, they are my friends.  I am forever grateful to this team for allowing me the great privilege to be apart of such an amazing movement to make the lives of the poorest people on the planet a little bit easier by having enough cassava.  This is one of many.
A few photos of our journey!
2 Comments

    Laura M. Boykin

    Computational Biologis | TED Fellow| I want to do science that matters for people that matter.  

    Archives

    December 2019
    December 2018
    December 2017
    November 2016

    Categories

    All

    RSS Feed

Contact   |   Cassava Virus Action Project
Picture
  

Updated August 27, 2022